The Immediate & Lasting Power of Spravato for PTSD and TRD

The Immediate & Lasting Power of Spravato for PTSD and TRD

The Albany Clinic • March 14, 2024

In the realm of mental health treatment, especially for Post-Traumatic Stress Disorder (PTSD) and Treatment-Resistant Depression (TRD), the emergence of innovative and effective solutions is always a cause for celebration. The introduction of a new service that has the potential to significantly impact the lives of individuals battling major depression marks a significant milestone in the field of psychiatry. In this article, we'll explore the background on depression and PTSD while introducing Spravato® as a innovative treatment option.

Background on Depression and PTSD

Major depression is a complex and debilitating condition that affects millions of individuals worldwide. Shockingly, between 20% to 70% of Americans diagnosed with major depression may experience treatment-resistant depression after failing at least two adequate trials of antidepressant medication. This staggering statistic highlights the urgent need for alternative and more effective treatment options.

Spravato®: An Innovation in Depression and PTSD Treatment

One groundbreaking solution that has garnered attention since its FDA approval in 2019 is Spravato® (esketamine) nasal spray. This innovative medication has shown promising results during clinical trials in rapidly bringing relief of depressive symptoms to patients grappling with major depression, including those experiencing suicidal thoughts. Furthermore, in clinical trials it has been proven that when combined with an oral antidepressant patients experienced significantly longer relief. The ability of Spravato® to provide swift, substantial, and long-lasting alleviation from depressive symptoms is a game-changer in the realm of mental health treatment.

The Eskatmine Difference

As a nasal spray derived from ketamine, esketamine offers an evidenced based treatment option for patients who have not found relief from traditional antidepressants. Unlike its precursor, ketamine which is administered intravenously, esketamine is administered nasally through a spray. This targeted approach allows for lower dosages, reducing potential side effects. Notably, it can rapidly alleviate symptoms, including suicidal ideation—a vital benefit highlighted by Johns Hopkins Medicine. This novel treatment requires administration under medical supervision due to initial side effects, emphasizing its safe and controlled use.

If you feel treatment for depression isn’t working, talk to your psychiatrist to see if esketamine therapy is an option for you. If you're local to Carbondale Illinois, we can help!

What qualifies you for SPRAVATO®?

Spravato®, a treatment for those with severe depression not responding to conventional medications, is covered by most major insurance policies and designed for medicinal use, distinctly from its ketamine counterpart. It's important to dispel misinformation about Spravato® and ketamine, recognizing Spravato's role in treating depression effectively. However, it's not suitable for everyone, especially individuals with cardiovascular issues or a history of substance abuse, due to risks associated with blood pressure elevation and potential for misuse.


A few other risk factors must be taken into consideration so be sure to tell your provider if you have heart, brain or liver problems, you have ever had psychosis (see, feel, or hear things that aren't there, or believe in things that aren't true), or if you are pregnant or breastfeeding. All prescription or over-the-counter medicines, including vitamins or herbal supplements, must be disclosed to your healthcare professional.


At your appointment your healthcare professional will discuss common side effects with you before deciding if Spravato® is right for you in treating your symptoms of depression.

Clinical Trials and Studies on Spravato®

» Swift Delivery

What sets Spravato® apart from traditional oral antidepressant medications is its unique mode of administration. As a nasal spray, Spravato® bypasses the digestive system and is directly absorbed into the bloodstream through the nasal mucosa. This alternative route of delivery allows for faster onset of action and more targeted delivery of the medication to the brain, resulting in quicker relief for patients in distress.


» Enhanced Access to Life-Saving Medication

Albany Clinic's commitment to providing greater access to Spravato® is a testament to our dedication to improving mental health care. By offering this potentially life-saving medication to patients in need, we are bridging the gap for individuals whose depressive disorder has not responded to conventional treatment methods. The impact of this increased accessibility cannot be overstated in the realm of mental health treatment.


» Future Directions for Spravato® in Depression and PTSD Treatment

Further supporting this breakthrough treatment option, in March 2024 the UConn Health Department of Psychiatry launched a new eskatemine service which represents a significant opportunity to contribute to the scientific literature surrounding this new medicine. Through research, clinical trials, and scholarly collaborations, UConn Health aims to expand understanding of the efficacy and potential applications of Spravato®, paving the way for future advancements in the field of mental health treatment.

Clinical Trials and Studies on Spravato®

Curious about how esketamine service works? Let's dive in and explore the process step by step.


» The Nasal Spray Administration

Once your physician has determined you meet the criteria for esketamine treatment they will administer the nasal spray. Each patient at Albany Clinic is carefully attended to by their treating provider. The nasal spray is expertly administered in the office to ensure the safety and comfort of every individual undergoing treatment.


» Treatment Schedule

Patients receiving esketamine follow a customized treatment schedule. Initially, patients may receive the nasal spray frequently. Following this intensive phase, the frequency of administration may reduced based on results in reducing depressive symptoms. This structured approach aims to optimize the therapeutic benefits of esketamine for patients and help to reduce common side effects.


» Continuation of Treatment

After the initial period of treatment, patients may continue receiving esketamine on a less frequent basis based on an assessment by their provider. This flexibility allows for personalized treatment plans tailored to each individual's needs. Qualified providers at The Albany Clinic work closely with patients to determine the most effective and sustainable long-term treatment strategy.


» The Powerful Potential of Combining Esketamine Treatment with Therapy

One of the most promising avenues in mental health treatment for depressive disorders such as PTSD and TRD involves the fusion of esketamine with therapy and oral antidepressants. When combined with therapy, such as cognitive-behavioral therapy (CBT) or psychotherapy, esketamine treatment can potentially enhance the overall efficacy of treatment by addressing both the biological and psychological aspects of depression.

The synergistic effect of esketamine and therapy holds the promise of not just alleviating symptoms but also addressing the underlying causes of depression, leading to more sustainable and long-term recovery outcomes for individuals battling treatment-resistant depression.

the word spravato is on a white background

Conclusion & Support

As we look ahead to the future of mental health treatment, the emergence of new services that combine esketamine treatment with traditional therapies offers a dual ability to contribute to the treatment of post-traumatic stress disorder and treatment resistant depression. By integrating cutting-edge pharmacological interventions with evidence-based psychological approaches, these services have the potential to address the complex and multifaceted nature of depression more comprehensively.


Furthermore, by grounding their practice in the evidence base that guides the mental health field, these innovative services not only provide clinical benefits to individuals seeking relief from depression but also contribute to the advancement of scientific knowledge and best practices in mental health care.


Together, the collaborative efforts of researchers, clinicians, and institutions like UConn School of Medicine and John Hopkins Medicine pave the way for clinics like The Albany Clinic to envision a future where individuals with treatment-resistant depression have access to more effective and holistic treatment options that promote healing and recovery.


Seeking Help for Severe Depression or Suicidal Thoughts

Struggling with severe depression or suicidal thoughts is an urgent matter that requires immediate attention and care. If you or someone you know is in crisis, it's essential to take action to ensure safety and well-being.


Alert Your Psychiatric Provider Immediately

If you have a psychiatric provider or therapist, let them know about your current state as soon as possible. They can offer support, guidance, and even make adjustments to your treatment plan to provide you with the help you need.


Get Help by Calling 9-1-1, 2-1-1, or the National Suicide & Crisis Hotline 988

If you do not have a psychiatric provider or if the situation is urgent, do not hesitate to reach out for help immediately. You can call emergency services by dialing 9-1-1, contact a local crisis helpline such as 2-1-1, or connect with the National Suicide & Crisis Hotline by dialing 988. These resources are available 24/7 to provide support and assistance during times of crisis.


The Albany Clinic in Carbondale Illinois invites you to
reach out for expert guidance and support on your journey towards healing and stability. We offer Spravato® treatment as well as traditional ketamine infusion, TMS therapy, and other services to help with depression.

35 Albany Rd. Suite A Carbondale, IL 62903

Phone:     (888) 804-4330

Source:

Daly, Ella J et al. “Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial.” JAMA psychiatry vol. 76,9 (2019): 893-903. doi:10.1001/jamapsychiatry.2019.1189

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By Matt Rodriguez April 1, 2025
Finding effective depression treatment can be challenging, especially when cost and insurance coverage add to the stress. Fortunately, for individuals in Illinois, several advanced, insurance-backed options are available beyond traditional antidepressants and therapy. This article explores innovative treatments for depression that are available at our Albany Clinic in Carbondale. Addressing the Need for Affordable Depression Relief in Illinois Depression remains a significant public health concern in Illinois. In 2023, data showed that 18.1% of all adults in the state had a doctor's diagnosis of a depressive disorder . Traditional first-line treatments for depression include medications such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). However, these are not universally effective; approximately one-third of patients are treatment-resistant. 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Enhanced plasticity may improve the function of nerve circuits responsible for mood regulation, increasing overall well-being. A typical Spravato treatment involves sessions administered under medical supervision, starting with twice-weekly doses and then tapering as appropriate. Whereas antidepressants typically take around four weeks to show an effect, Spravato can have rapid action at alleviating symptoms. A study found that Spravato significantly reduced depression symptoms compared to a placebo drug within just 24 hours of administration. Does Insurance cover Spravato? Due to its FDA approval, Spravato is covered by most major insurance plans in Illinois, including Medicare and Medicaid. However, only patients with a formal diagnosis of treatment-resistant depression (TRD) or major depressive disorder with suicidal ideation (MDSI) are eligible for the treatment. While the medication is usually covered by insurance, patients may still have out-of-pocket costs , including copays , deductibles , and pre-treatment medical evaluations . Your exact expenses will depend on your specific insurance plan. At the Albany Clinic, we’re here to help you understand your costs and maximize your coverage. Transcranial Magnetic Stimulation (TMS) Therapy What is TMS, and how does it work? TMS therapy is a noninvasive procedure that uses magnetic fields to stimulate underactive regions of the brain associated with mood regulation. In depression, TMS targets the dorsolateral prefrontal cortex (DLPFC) , which is often less active in individuals with the condition. TMS therapy works by: Inducing electrical activity in neurons , prompting the release of neurotransmitters involved in mood and motivation. Increasing the activity of neural circuits responsible for mood regulation. Enhancing neuroplasticity , potentially “re-wiring” nerve circuits associated with unhealthy thinking and behavior. The treatment protocol typically consists of daily sessions over several weeks. Each session lasts about 20-40 minutes, during which patients remain awake and alert. Does insurance cover TMS? Since TMS therapy is FDA-approved, some major insurance providers in Illinois cover costs, but unfortunately, the state’s Medicaid does not. If you're considering TMS, check with your insurance provider to see if your plan includes coverage, as eligibility and benefits vary. At the Albany Clinic, we're here to help clarify details and explore options to make treatment more affordable. IV Ketamine Infusion Therapy What is an IV ketamine infusion and how does it work? IV ketamine infusion therapy involves administering ketamine intravenously at sub-anesthetic doses . 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Here are steps to help streamline the process: Verify Coverage : Contact your insurance provider to inquire about treatment coverage specifics. Some insurers require a history of treatment failures with traditional antidepressants before approving coverage for these advanced therapies. Obtain Pre-Authorization : Many insurers require pre-authorization for certain treatments. Ensure all necessary approvals are secured before initiating therapy. The Albany Clinic's administrative team can assist in submitting pre-authorization requests. Understand Financial Responsibilities : Clarify any co-pays, deductibles, or out-of-pocket expenses associated with your treatment plan. Consult Our Team : The Albany Clinic's administrative staff is experienced in navigating insurance processes and can assist you in understanding and managing the financial aspects of your treatment. We also provide financial counseling to help patients explore payment plans and reimbursement options. Going Forward Navigating insurance for depression treatment can be complex, but you don’t have to do it alone. At The Albany Clinic , we’re dedicated to helping patients access effective, insurance-backed treatments while minimizing out-of-pocket costs. Contact us today to learn more about your options and take the next step toward relief.
By Matt Rodriguez March 3, 2025
Struggling with a social anxiety disorder (SAD) can feel isolating and overwhelming, especially when other medications haven’t proved effective. However, ketamine therapy offers a promising path forward, showing fast and significant relief from SAD symptoms. At The Albany Clinic in Albany, New York, we provide customized ketamine treatment plans designed to empower patients to overcome the challenges of SAD. Read on to explore the science and benefits of this transformative approach. Understanding Social Anxiety Disorder Social Anxiety Disorder (SAD), often referred to as social phobia, is a chronic mental health condition characterized by extreme fear and discomfort in social situations. While occasional nervousness in social settings is normal, social anxiety disorder is more persistent and can significantly disrupt daily life, relationships, and career opportunities. According to the National Institute of Mental Health (NIMH) , 7.1% of the U.S. population experiences social anxiety disorder annually. Recognizing the Symptoms of SAD The symptoms of social anxiety disorder can be grouped into three categories: emotional, behavioral, and physical. Emotional Symptoms: Intense fear of social interactions, particularly with strangers. Persistent worry about being judged or negatively evaluated. Excessive anxiety about upcoming social events, often for weeks in advance. Overwhelming self-consciousness in social environments. Behavioral Symptoms: Avoidance of social situations. Skipping school, work, or events to avoid social interaction. Relying on alcohol or other substances to ease anxiety in social settings. Physical Symptoms: Sweating, trembling, dry mouth, or muscle tension. Panic attacks in extreme cases. 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Studies suggest that this region may become dysfunctional in SAD, but ketamine could help restore its normal function and reduce SAD symptoms. Ketamine also lowers the activity of the amygdala , a brain region linked to fear and the body’s stress response. In people with anxiety, the amygdala is often overactive. Ketamine may help by calming this overactivity and reducing feelings of fear. Benefits of Ketamine for SAD Ketamine offers several benefits for treating SAD . One of its most significant advantages is its rapid action , often providing relief within hours, compared to the weeks or months traditional antidepressants can take. Additionally, ketamine has shown sustained effects , with a single dose sometimes improving symptoms for days or even weeks. Whereas common anti-anxiety medications, such as antidepressants, are used every day, ketamine is used more infrequently . A typical dosing regime involves twice-weekly sessions for the first four weeks, with more spaced-out sessions thereafter. This prevents people from developing tolerance to the drug, so they don’t experience withdrawal symptoms once they stop taking medication. However, ketamine does have an abuse potential , and ketamine addiction can lead to severe health consequences. For this reason, it’s essential to use ketamine in carefully controlled clinical environments under medical supervision, such as our clinic in Albany. Typical anti-anxiety medication is also associated with side effects that affect daily function, such as weight gain or sexual dysfunction . Ketamine, on the other hand, has mild side effects that generally wear off once the drug is cleared from the system. These include: Dizziness Decreased heart rate and blood pressure Drowsiness Nausea Research Supporting Ketamine for Social Anxiety A clinical trial from Yale University found ketamine infusions significantly decreased measures of social phobia in anxiety patients, compared to a placebo drug. The difference in improvement was significant from two days post-treatment and lasted up to the two-week follow-up. In another study from the University of Otago, patients with both generalized anxiety disorder (GAD) and SAD had significantly improved symptoms two weeks following ketamine treatment. These patients had been previously non-responsive to other therapies. Is Ketamine Therapy Right for You? Ketamine therapy is not suitable for everyone, but it can be highly effective for those who have not found relief with traditional treatments. You may be a good candidate if: You have been diagnosed with SAD, or another severe form of anxiety Conventional medications or therapies have not provided sufficient relief You are seeking a treatment with faster results However, ketamine therapy may not be recommended if you have: A current or past history of substance abuse You have specific liver or heart conditions You have a history of psychosis At The Albany Clinic, our experienced providers will carefully evaluate your medical history to determine if ketamine therapy is the best option for you. Building a Social Anxiety Treatment Plan at The Albany Clinic Step 1: Initial Consultation Your journey begins with a complimentary consultation to discuss whether ketamine therapy is suitable for you. During this session, our team will answer your questions, assess your mental health history, and develop a personalized treatment plan aligned with your recovery goals. 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If you are struggling with social anxiety disorder and looking for an innovative approach to enhance your mental health, The Albany Clinic in Albany, NY, offers expert-led ketamine therapy designed to meet your needs. Our compassionate team is committed to providing evidence-based treatment plans to help you regain control and live a fulfilling life. To find out if ketamine therapy is the right choice for you, schedule a complimentary consultation with one of our specialists today.
By Kimberly Mercille January 22, 2025
In this article, we’ll explore how TMS and antidepressants work, compare their effectiveness, safety, and costs, and help you determine which treatment might be right for you. Whether you’re considering TMS, antidepressants, or a combination of both, understanding your options can empower you to make an informed decision about your mental health journey.
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